| Chivas USA vs. Houston Dynamo | Carson, CA | Home Depot Center - Soccer Stadium | Mar 11, 2012 Sun 4:00PM | View Tickets |
| San Jose Earthquakes vs. Houston Dynamo (Doubleheader: Mexico vs. Senegal) | San Francisco, CA | AT&T Park | Mar 17, 2012 Sat 2:00PM | View Tickets |
| Seattle Sounders FC vs. Houston Dynamo | Seattle, WA | CenturyLink Field (Formerly Qwest Field) | Mar 23, 2012 Fri 7:00PM | View Tickets |
| Chicago Fire vs. Houston Dynamo | Bridgeview, IL | Toyota Park (formerly Bridgeview Stadium) | Apr 15, 2012 Sun 6:00PM | View Tickets |
| Columbus Crew vs. Houston Dynamo | Columbus, OH | Columbus Crew Stadium | Apr 21, 2012 Sat 7:30PM | View Tickets |
| D.C. United vs. Houston Dynamo | Washington, DC | Rfk Stadium | Apr 28, 2012 Sat 7:30PM | View Tickets |
| New York Red Bulls vs. Houston Dynamo | Harrison, NJ | Red Bull Arena - NJ | May 09, 2012 Wed 7:00PM | View Tickets |
| Houston Dynamo vs. D.C. United | Houston, TX | BBVA Compass Stadium | May 12, 2012 Sat 3:30PM | View Tickets |
| Houston Dynamo vs. Portland Timbers | Houston, TX | BBVA Compass Stadium | May 15, 2012 Tue 7:30PM | View Tickets |
| New England Revolution vs. Houston Dynamo | Foxborough, MA | Gillette Stadium | May 19, 2012 Sat 7:30PM | View Tickets |
| Houston Dynamo vs. Los Angeles Galaxy | Houston, TX | BBVA Compass Stadium | May 26, 2012 Sat 1:30PM | View Tickets |
| Vancouver Whitecaps FC vs. Houston Dynamo | Vancouver, Canada | Bc Place Stadium | Jun 10, 2012 Sun 4:00PM | View Tickets |
| Houston Dynamo vs. FC Dallas | Houston, TX | BBVA Compass Stadium | Jun 16, 2012 Sat 4:00PM | View Tickets |
| Houston Dynamo vs. Toronto FC | Houston, TX | BBVA Compass Stadium | Jun 20, 2012 Wed 8:00PM | View Tickets |
| Montreal Impact vs. Houston Dynamo | Montreal, Canada | Stade Saputo | Jun 23, 2012 Sat 7:30PM | View Tickets |
| Houston Dynamo vs. Philadelphia Union | Houston, TX | BBVA Compass Stadium | Jun 30, 2012 Sat 7:30PM | View Tickets |
| Houston Dynamo vs. Chicago Fire | Houston, TX | BBVA Compass Stadium | Jul 03, 2012 Tue 7:30PM | View Tickets |
| Sporting Kansas City vs. Houston Dynamo | Kansas City, KS | Livestrong Sporting Park - KC | Jul 07, 2012 Sat 7:30PM | View Tickets |
| Houston Dynamo vs. D.C. United | Houston, TX | BBVA Compass Stadium | Jul 15, 2012 Sun 8:00PM | View Tickets |
| Houston Dynamo vs. Sporting Kansas City | Houston, TX | BBVA Compass Stadium | Jul 18, 2012 Wed 7:30PM | View Tickets |
| Houston Dynamo vs. Montreal Impact | Houston, TX | BBVA Compass Stadium | Jul 21, 2012 Sat 7:30PM | View Tickets |
| Toronto FC vs. Houston Dynamo | Toronto, Canada | BMO Field | Jul 28, 2012 Sat 4:30PM | View Tickets |
| Houston Dynamo vs. New York Red Bulls | Houston, TX | BBVA Compass Stadium | Aug 03, 2012 Fri 7:00PM | View Tickets |
| New York Red Bulls vs. Houston Dynamo | Harrison, NJ | Red Bull Arena - NJ | Aug 10, 2012 Fri 8:00PM | View Tickets |
| Houston Dynamo vs. Columbus Crew | Houston, TX | BBVA Compass Stadium | Aug 19, 2012 Sun 8:00PM | View Tickets |
| Houston Dynamo vs. Toronto FC | Houston, TX | BBVA Compass Stadium | Aug 25, 2012 Sat 7:30PM | View Tickets |
| Chicago Fire vs. Houston Dynamo | Bridgeview, IL | Toyota Park (formerly Bridgeview Stadium) | Sep 02, 2012 Sun 6:00PM | View Tickets |
| Houston Dynamo vs. Real Salt Lake | Houston, TX | BBVA Compass Stadium | Sep 06, 2012 Thu 7:30PM | View Tickets |
| Sporting Kansas City vs. Houston Dynamo | Kansas City, KS | Livestrong Sporting Park - KC | Sep 14, 2012 Fri 7:30PM | View Tickets |
| Philadelphia Union vs. Houston Dynamo | Chester, PA | PPL Park | Sep 23, 2012 Sun 5:00PM | View Tickets |
| Houston Dynamo vs. New England Revolution | Houston, TX | BBVA Compass Stadium | Sep 29, 2012 Sat 7:30PM | View Tickets |
| Houston Dynamo vs. Montreal Impact | Houston, TX | BBVA Compass Stadium | Oct 06, 2012 Sat 7:30PM | View Tickets |
| Houston Dynamo vs. Philadelphia Union | Houston, TX | BBVA Compass Stadium | Oct 20, 2012 Sat 6:30PM | View Tickets |
| Colorado Rapids vs. Houston Dynamo | Commerce City, CO | Dick's Sporting Goods Park | Oct 27, 2012 Sat 7:00PM | View Tickets |